| Gene Information | |
|---|---|
| Gene Name | YTHDC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 727 |
| Protein Names | YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000083896 ) 3 ( ENSG00000275272 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96MU7 |
| Gene Card | YTHDC1 |
| Uniprot ID | Q96MU7 |
| Pfam | PF04146 |
| In ASD | no |
| Allosteric Prediction | no (-0.999963998) |
| Ortholog in Animals | Alpaca_ YTHDC1 ( ortholog_one2one ) Dog_ YTHDC1 ( ortholog_one2one ) GuineaPig_ YTHDC1 ( ortholog_one2one ) Macaque_ YTHDC1 ( ortholog_one2one ) Mouse_ Ythdc1 ( ortholog_one2one ) Pig_ YTHDC1 ( ortholog_one2one ) Rat_ Ythdc1 ( ortholog_one2one ) Rabbit_ YTHDC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | YTHDF1, YTHDF3, YTHDF2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.031579(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YUD (NMR - ) 4R3H (X-ray 1.90A ) 4R3I (X-ray 1.80A ) 6RT4 (X-ray 1.49A ) 6RT5 (X-ray 2.30A ) 6RT6 (X-ray 1.46A ) 6RT7 (X-ray 1.73A ) 6SYZ (X-ray 2.28A ) 6SZ1 (X-ray 1.75A ) 6SZ2 (X-ray 1.52A ) 6SZ3 (X-ray 1.28A ) 6SZL (X-ray 1.45A ) 6SZN (X-ray 1.47A ) 6SZR (X-ray 1.64A ) 6SZT (X-ray 1.50A ) 6SZX (X-ray 1.17A ) 6SZY (X-ray 1.79A ) 6T01 (X-ray 1.50A ) 6T02 (X-ray 1.10A ) 6T03 (X-ray 1.50A ) 6T04 (X-ray 1.50A ) 6T05 (X-ray 1.50A ) 6T06 (X-ray 2.40A ) 6T07 (X-ray 1.50A ) 6T08 (X-ray 1.41A ) 6T09 (X-ray 1.75A ) 6T0A (X-ray 2.02A ) 6T0C (X-ray 2.03A ) 6T0D (X-ray 1.43A ) 6T0O (X-ray 1.71A ) 6T0X (X-ray 1.36A ) 6T0Z (X-ray 1.43A ) 6T10 (X-ray 1.48A ) 6T11 (X-ray 1.49A ) 6T12 (X-ray 1.46A ) 6WE8 (X-ray 1.18A ) 6WE9 (X-ray 1.59A ) 6WEA (X-ray 1.80A ) 6YKE (X-ray 1.52A ) 6YKI (X-ray 1.30A ) 6YKJ (X-ray 1.60A ) 6YKZ (X-ray 1.20A ) 6YL0 (X-ray 1.20A ) 6YL8 (X-ray 1.50A ) 6YL9 (X-ray 1.50A ) 6YM2 (X-ray 1.70A ) 6YM6 6YM8 (X-ray 1.50A ) 6YNI (X-ray 1.36A ) 6YNJ (X-ray 1.50A ) 6YNK (X-ray 1.30A ) 6YNL (X-ray 1.50A ) 6YNM (X-ray 1.50A ) 6YNN (X-ray 1.20A ) 6YNO (X-ray 1.40A ) 6YNP (X-ray 1.10A ) 6YOQ (X-ray 1.30A ) 6ZCM (X-ray 1.24A ) 6ZCN (X-ray 1.60A ) 6ZD9 (X-ray 1.51A ) 7L4X (X-ray 1.79A ) 7L4Y (X-ray 1.79A ) 7P87 (X-ray 1.30A ) 7P88 (X-ray 1.50A ) 7P8A (X-ray 1.70A ) 7P8B (X-ray 1.20A ) 7P8F (X-ray 1.50A ) 7PJ7 (X-ray 1.41A ) 7PJ8 (X-ray 1.40A ) 7PJ9 (X-ray 1.72A ) 7PJA (X-ray 1.85A ) 7PJB (X-ray 1.90A ) 7PJP (X-ray 1.61A ) 7PJQ (X-ray 1.20A ) 7PO6 (X-ray 1.77A ) |
| DBSNP | rs3813832 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20167602}. Nucleus speckle {ECO:0000269|PubMed:26876937}. Note=Localizes to a novel subnuclear structure, the YT bodies. {ECO:0000250|UniProtKB:Q9QY02}. |
| Mouse PG classification | NA |
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