| Gene Information | |
|---|---|
| Gene Name | HLA-DQA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 254 |
| Protein Names | HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000196735 ) 3 ( ENSG00000206305 ) 3 ( ENSG00000225890 ) 3 ( ENSG00000228284 ) 3 ( ENSG00000232062 ) 3 ( ENSG00000236418 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P01909 |
| Gene Card | HLA-DQA1 |
| Uniprot ID | P01909 |
| Pfam | PF07654; PF00993 |
| In ASD | no |
| Allosteric Prediction | yes (0.304564422) |
| Ortholog in Animals | Alpaca_ HLA-DQA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HLA-DPB1, HLA-DPA1, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DRA, HLA-DRB5, HLA-DRB1, B2M, HLA-DQB1, HLA-DQB2, HLA-DMA, HLA-DQA2 |
| Tissue | lung, spleen |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JK8 (X-ray 2.40A ) 1S9V (X-ray 2.22A ) 1UVQ (X-ray 1.80A ) 2NNA (X-ray 2.10A ) 4GG6 (X-ray 3.20A ) 4OZF (X-ray 2.70A ) 4OZG (X-ray 3.00A ) 4OZH (X-ray 2.80A ) 4OZI (X-ray 3.20A ) 5KSA (X-ray 2.00A ) 5KSB (X-ray 2.90A ) 5KSU (X-ray 2.73A ) 5KSV (X-ray 2.19A ) 6MFF (X-ray 2.60A ) 6MFG (X-ray 2.00A ) 6U3M (X-ray 1.90A ) 6U3N (X-ray 2.80A ) 6XP6 (X-ray 2.40A ) 7SG0 (X-ray 3.00A ) 7SG1 (X-ray 3.10A ) 7SG2 (X-ray 3.10A ) |
| DBSNP | rs1047989 rs1047992 rs12722039 rs11545686 rs41545012 rs12722042 rs1129740 rs1071630 rs41549715 rs12722051 rs1048023 rs10093 rs1142323 rs36219699 rs41543221 rs1142324 rs1142326 rs3207983 rs1142328 rs760671632 rs3208105 rs12722061 rs9272698 rs28383449 rs9272699 rs1048052 rs12722069 rs3188043 rs4193 rs41541412 rs1142333 rs1142334 rs9279910 rs1064944 rs1064944 rs41542116 rs1129808 rs41555012 rs707952 rs707950 rs41547417 rs41545514 rs41544114 rs41552014 rs41550317 rs707949 rs7990 rs41561312 rs707963 rs707962 rs2308891 rs2308891 rs9272785 rs35087390 rs9260 rs41545416 rs1048430 rs1048439 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. |
| Mouse PG classification | NA |
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