| Gene Information | |
|---|---|
| Gene Name | ZMPSTE24 |
| Organism | Homo sapiens (Human) |
| Gene Length | 475 |
| Protein Names | CAAX prenyl protease 1 homolog (EC 3.4.24.84) (Farnesylated proteins-converting enzyme 1) (FACE-1) (Prenyl protein-specific endoprotease 1) (Zinc metalloproteinase Ste24 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000084073 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O75844 |
| Gene Card | ZMPSTE24 |
| Uniprot ID | O75844 |
| Pfam | PF01435; PF16491 |
| In ASD | no |
| Allosteric Prediction | no (-0.620086172) |
| Ortholog in Animals | Alpaca_ ZMPSTE24 ( ortholog_one2one ) Dog_ ZMPSTE24 ( ortholog_one2one ) GuineaPig_ ZMPSTE24 ( ortholog_one2one ) Macaque_ ZMPSTE24 ( ortholog_one2one ) Mouse_ Zmpste24 ( ortholog_one2one ) Pig_ ZMPSTE24 ( ortholog_one2one ) Rat_ Zmpste24 ( ortholog_one2one ) Rabbit_ ZMPSTE24 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High levels in kidney, prostate, testis and ovary. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2YPT (X-ray 3.80A ) 4AW6 (X-ray 3.40A ) 5SYT (X-ray 2.00A ) 6BH8 (X-ray 3.85A ) |
| DBSNP | rs17853725 rs121908095 rs281875371 rs121908093 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000269|PubMed:23539603}. Nucleus inner membrane {ECO:0000269|PubMed:23539603}; Multi-pass membrane protein {ECO:0000269|PubMed:23539603}. Early endosome {ECO:0000269|PubMed:35283811}. Late endosome {ECO:0000269|PubMed:35283811}. |
| Mouse PG classification | NA |
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