| Gene Information | |
|---|---|
| Gene Name | PHLDA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 401 |
| Protein Names | Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000139289 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8WV24 |
| Gene Card | PHLDA1 |
| Uniprot ID | Q8WV24 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.565536552) |
| Ortholog in Animals | Alpaca_ PHLDA1 ( ortholog_one2one ) GuineaPig_ PHLDA1 ( ortholog_one2one ) Macaque_ PHLDA1 ( ortholog_one2one ) Mouse_ Phlda1 ( ortholog_one2one ) Pig_ PHLDA1 ( ortholog_one2one ) Rat_ Phlda1 ( ortholog_one2one ) Rabbit_ PHLDA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PHLDA3, PHLDA2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). {ECO:0000269|PubMed:12384558, ECO:0000269|PubMed:12738777}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11369516}. Cytoplasmic vesicle {ECO:0000269|PubMed:12738777}. Nucleus, nucleolus {ECO:0000269|PubMed:11369516}. Note=Colocalizes with intracellular vesicles. {ECO:0000269|PubMed:12738777}. |
| Mouse PG classification | NA |
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