| Gene Information | |
|---|---|
| Gene Name | YES1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 543 |
| Protein Names | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) |
| Target Name | yes tyrosine kinase |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000176105 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P07947 |
| Gene Card | YES1 |
| Uniprot ID | P07947 |
| Pfam | PF07714; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.98173927) |
| Ortholog in Animals | Alpaca_ YES1 ( ortholog_one2one ) Dog_ YES1 ( ortholog_one2one ) GuineaPig_ YES1 ( ortholog_one2one ) Macaque_ YES1 ( ortholog_one2one ) Mouse_ Yes1 ( ortholog_one2one ) Pig_ YES1 ( ortholog_one2one ) Rat_ Yes1 ( ortholog_one2one ) |
| Ohnologs | HCK, SRC, FGR, FYN, FRK, BLK, LCK |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, LCK, SRC, JAK2, ITK, MATK, TNK1, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Expressed in the epithelial cells of renal proximal tubules and stomach as well as hematopoietic cells in the bone marrow and spleen in the fetal tissues. In adult, expressed in epithelial cells of the renal proximal tubules and present in keratinocytes in the basal epidermal layer of epidermis. {ECO:0000269|PubMed:2021534, ECO:0000269|PubMed:2067846}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.034016(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2HDA (X-ray 1.90A ) |
| DBSNP | rs34580680 rs35126906 |
| Subcellular location [CC] | Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. |
| Mouse PG classification | NA |
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