| Gene Information | |
|---|---|
| Gene Name | YBX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Y-box-binding protein 2 (Contrin) (DNA-binding protein C) (Dbpc) (Germ cell-specific Y-box-binding protein) (MSY2 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000006047 ) 3 ( ENSG00000288504 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9Y2T7 |
| Gene Card | YBX2 |
| Uniprot ID | Q9Y2T7 |
| Pfam | PF00313 |
| In ASD | no |
| Allosteric Prediction | no (-1.267729985) |
| Ortholog in Animals | Alpaca_ YBX2 ( ortholog_one2many ) Dog_ YBX2 ( ortholog_one2one ) GuineaPig_ YBX2 ( ortholog_one2one ) Macaque_ YBX2 ( ortholog_one2one ) Mouse_ Ybx2 ( ortholog_one2one ) Pig_ YBX2 ( ortholog_one2one ) Rat_ Ybx2 ( ortholog_one2one ) Rabbit_ YBX2 ( ortholog_one2one ) |
| Ohnologs | YBX3, YBX1 |
| Paralogs | YBX1, LIN28A, LIN28B, YBX3 |
| Tissue | testis |
| Tissue Specificity | Expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Also observed placental trophoblasts, as well as in vascular smooth muscle cells in the pulmonary artery, myocardium, and skeletal muscle. Undetectable in epithelial cells in respiratory, gastrointestinal, and urogenital tracts. Up-regulated in various carcinomas and germ cell tumors (at protein level). {ECO:0000269|PubMed:10100484, ECO:0000269|PubMed:16479255}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7F3I (X-ray 2.25A ) 7F3J (X-ray 1.95A ) 7F3K (X-ray 1.76A ) 7F3L (X-ray 1.88A ) |
| DBSNP | rs222859 rs8069533 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16479255}. Nucleus {ECO:0000269|PubMed:16479255}. |
| Mouse PG classification | NA |
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