| Gene Information | |
|---|---|
| Gene Name | GNA13 |
| Organism | Homo sapiens (Human) |
| Gene Length | 377 |
| Protein Names | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000120063 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14344 |
| Gene Card | GNA13 |
| Uniprot ID | Q14344 |
| Pfam | PF00503 |
| In ASD | no |
| Allosteric Prediction | yes (1.329188585) |
| Ortholog in Animals | Alpaca_ GNA13 ( ortholog_one2one ) Dog_ GNA13 ( ortholog_one2one ) GuineaPig_ GNA13 ( ortholog_one2one ) Macaque_ GNA13 ( ortholog_one2one ) Mouse_ Gna13 ( ortholog_one2one ) Pig_ GNA13 ( ortholog_one2one ) Rat_ Gna13 ( ortholog_one2one ) Rabbit_ GNA13 ( ortholog_one2one ) |
| Ohnologs | GNA12 |
| Paralogs | GNAZ, GNAT1, GNAL, GNA12, GNAI2, GNAT2, GNAO1, GNAI3, GNAI1, GNA15, GNA11, GNAT3, GNAS, GNA14, GNAQ |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level). {ECO:0000269|PubMed:18703424}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7T6B (EM 3.19A ) |
| DBSNP | rs1062597 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10747909}; Lipid-anchor {ECO:0000269|PubMed:10747909}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000269|PubMed:10747909, ECO:0000269|PubMed:18703424}. Nucleus {ECO:0000269|PubMed:18703424}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18703424}. |
| Mouse PG classification | NA |
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