| Gene Information | |
|---|---|
| Gene Name | CYP2D6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 497 |
| Protein Names | Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase) |
| Target Name | debrisoquine 4-hydroxylase |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000100197 ) 3 ( ENSG00000275211 ) 3 ( ENSG00000280905 ) 3 ( ENSG00000282966 ) 3 ( ENSG00000283284 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10635 |
| Gene Card | CYP2D6 |
| Uniprot ID | P10635 |
| Pfam | PF00067 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000062857) |
| Ortholog in Animals | Alpaca_ CYP2D6 ( ortholog_one2one ) Dog_ CYP2D15 ( ortholog_one2one ) Macaque_ CYP2D6 ( ortholog_one2many ) Mouse_ Cyp2d26 ( ortholog_one2many ) Mouse_ Cyp2d34 ( ortholog_one2many ) Mouse_ Cyp2d9 ( ortholog_one2many ) Mouse_ Cyp2d10 ( ortholog_one2many ) Mouse_ Cyp2d11 ( ortholog_one2many ) Mouse_ Cyp2d40 ( ortholog_one2many ) Mouse_ Cyp2d22 ( ortholog_one2many ) Mouse_ Cyp2d12 ( ortholog_one2many ) Mouse_ Cyp2d13 ( ortholog_one2many ) Pig_ CYP2D6 ( ortholog_one2one ) Rat_ Cyp2d4 ( ortholog_one2many ) Rat_ Cyp2d2 ( ortholog_one2many ) Rat_ Cyp2d5 ( ortholog_one2many ) Rat_ Cyp2d3 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CYP2S1, CYP2W1, CYP2C18, CYP2C9, CYP2C19, CYP2B6, CYP2C8, CYP2U1, CYP2A6, CYP2A7, CYP2A13, CYP2F1, CYP2R1, CYP2E1, CYP2J2 |
| Tissue | liver, small.intestine |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2F9Q (X-ray 3.00A ) 3QM4 (X-ray 2.85A ) 3TBG (X-ray 2.10A ) 3TDA (X-ray 2.67A ) 4WNT (X-ray 2.60A ) 4WNU (X-ray 2.26A ) 4WNV (X-ray 2.35A ) 4WNW (X-ray 3.30A ) 4XRY (X-ray 2.50A ) 4XRZ (X-ray 2.40A ) 5TFT (X-ray 2.71A ) 5TFU (X-ray 2.75A ) 6CSB (X-ray 2.39A ) 6CSD (X-ray 2.39A ) |
| DBSNP | rs773790593 rs769258 rs138417770 rs28371696 rs138100349 rs1065852 rs5030862 rs267608310 rs28371703 rs28371704 rs76187628 rs28371706 rs1135822 rs375135093 rs569229126 rs28371710 rs5030865 rs5030866 rs567606867 rs371793722 rs17002853 rs28371717 rs16947 rs949717872 rs1058170 rs1800754 rs5030867 rs3915951 rs745746329 rs748712690 rs750996195 rs267608295 rs76088846 rs1058172 rs61737946 rs769157652 rs28371733 rs777560972 rs1135833 rs28371735 rs1135840 rs370580423 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein. |
| Mouse PG classification | NA |
| click here to return to the previous page | |