| Gene Information | |
|---|---|
| Gene Name | YARS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 528 |
| Protein Names | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134684 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P54577 |
| Gene Card | YARS1 |
| Uniprot ID | P54577 |
| Pfam | PF00579; PF01588 |
| In ASD | no |
| Allosteric Prediction | yes (0.137863091) |
| Ortholog in Animals | Alpaca_ YARS1 ( ortholog_one2one ) Dog_ YARS1 ( ortholog_one2one ) GuineaPig_ YARS1 ( ortholog_one2one ) Macaque_ YARS1 ( ortholog_one2one ) Mouse_ Yars ( ortholog_one2one ) Pig_ YARS1 ( ortholog_one2one ) Rat_ Yars1 ( ortholog_one2one ) Rabbit_ YARS1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1N3L (X-ray 1.18A ) 1NTG (X-ray 2.21A ) 1Q11 (X-ray 1.60A ) 4Q93 (X-ray 2.10A ) 4QBT (X-ray 2.10A ) 5THH (X-ray 1.96A ) 5THL (X-ray 1.60A ) 7ROU (X-ray 1.70A ) |
| DBSNP | rs121908833 rs2128600 rs121908834 rs758897498 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16429158, ECO:0000269|PubMed:30304524, ECO:0000305|PubMed:9162081}. Nucleus {ECO:0000269|PubMed:22291016, ECO:0000269|PubMed:25533949}. Note=Cytoplasmic in normal conditions (PubMed:25533949). Resveratrol-binding in response to serum starvation promotes relocalization to the nucleus (PubMed:25533949). {ECO:0000269|PubMed:25533949}. |
| Mouse PG classification | NA |
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