Gene Information
Gene NameYAP65
OrganismHomo sapiens (Human)
Gene Length504
Protein NamesTranscriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBP46937
Gene CardYAP1
Uniprot IDP46937
PfamPF00397
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityIncreased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). {ECO:0000269|PubMed:16461361, ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:7782338}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.008084(Rat);0.054334(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1JMQ  (NMR  -  )  1K5R  (NMR  -  )  1K9Q  (NMR  -  )  1K9R  (NMR  -  )  2LAW  (NMR  -  )  2LAX  (NMR  -  )  2LAY  (NMR  -  )  2LTV  (NMR  -  )  2LTW  (NMR  -  )  3KYS  (X-ray  2.80A  )  3MHR  (X-ray  1.15A  )  4RE1  (X-ray  2.20A  )  4REX  (X-ray  1.60A  )  5OAQ  (X-ray  1.95A  )  5YDX  (NMR  -  )  5YDY  (NMR  -  )  6G6X  (X-ray  1.13A  )  6G8I  (X-ray  1.60A  )  6G8J  (X-ray  1.47A  )  6G8K  (X-ray  1.25A  )  6G8L  (X-ray  1.37A  )  6G8P  (X-ray  1.90A  )  6G8Q  (X-ray  1.85A  )  6GE3  (X-ray  1.85A  )  6GE4  (X-ray  1.97A  )  6GE5  (X-ray  2.05A  )  6GE6  (X-ray  1.80A  )  6GEC  (X-ray  1.70A  )  6GEE  (X-ray  1.96A  )  6GEG  (X-ray  2.23A  )  6GEI  (X-ray  1.65A  )  6GEK  (X-ray  2.28A  )  6HIK  (X-ray  1.65A  )  6HIL  (X-ray  2.30A  )  6Q2X  (X-ray  2.10A  )  7O07  (X-ray  1.20A  ) 
DBSNP rs1162286204  rs376161041  rs777949318 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865}. Nucleus {ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:18280240, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:28169360, ECO:0000269|PubMed:30447097}. Note=Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). {ECO:0000250|UniProtKB:P46938, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:22525271, ECO:0000269|PubMed:25849865}.
Mouse PG classificationNA
click here to return to the previous page