| Gene Information | |
|---|---|
| Gene Name | XRN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 950 |
| Protein Names | 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000088930 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H0D6 |
| Gene Card | XRN2 |
| Uniprot ID | Q9H0D6 |
| Pfam | PF17846; PF03159 |
| In ASD | no |
| Allosteric Prediction | no (-0.902347419) |
| Ortholog in Animals | Alpaca_ XRN2 ( ortholog_one2one ) Dog_ XRN2 ( ortholog_one2one ) GuineaPig_ XRN2 ( ortholog_one2one ) Macaque_ XRN2 ( ortholog_one2one ) Mouse_ Xrn2 ( ortholog_one2one ) Pig_ XRN2 ( ortholog_one2one ) Rat_ Xrn2 ( ortholog_one2one ) Rabbit_ XRN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XRN1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes. {ECO:0000269|PubMed:10409438, ECO:0000269|PubMed:16147866}. |
| Pharmacological Animal Models | 0.007672(Chimpanzee);0.001000(Mouse);0.002925(Rat);0.041176(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs6137324 rs6047420 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. |
| Mouse PG classification | NA |
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