| Gene Information | |
|---|---|
| Gene Name | XRCC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 732 |
| Protein Names | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000079246 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P13010 |
| Gene Card | XRCC5 |
| Uniprot ID | P13010 |
| Pfam | PF02735; PF03730; PF03731; PF08785 |
| In ASD | no |
| Allosteric Prediction | yes (0.635835237) |
| Ortholog in Animals | Alpaca_ XRCC5 ( ortholog_one2one ) Dog_ XRCC5 ( ortholog_one2one ) GuineaPig_ XRCC5 ( ortholog_one2one ) Macaque_ XRCC5 ( ortholog_one2one ) Mouse_ Xrcc5 ( ortholog_one2one ) Pig_ XRCC5 ( ortholog_one2one ) Rat_ Xrcc5 ( ortholog_one2one ) Rabbit_ XRCC5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XRCC6 |
| Tissue | substantia.nigra |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.321733(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JEQ (X-ray 2.70A ) 1JEY (X-ray 2.50A ) 1Q2Z (NMR - ) 1RW2 (NMR - ) 3RZ9 (X-ray 2.29A ) 5Y3R (EM 6.60A ) 6ERF (X-ray 3.01A ) 6ERG (X-ray 2.90A ) 6ERH (X-ray 2.80A ) 6ZH6 (EM 3.93A ) 6ZHA (EM 3.91A ) 6ZHE (EM 7.24A ) 7AXZ (EM 3.20A ) 7K0Y (EM 3.70A ) 7K17 (X-ray 4.30A ) 7K1J (EM 3.90A ) 7K1K (EM 4.10A ) 7K1N (EM 3.90A ) 7LSY (EM 8.40A ) 7LT3 (EM 4.60A ) 7NFC (EM 4.14A ) 7NFE (EM 4.29A ) 7SGL (EM 3.00A ) 7SU3 (EM 3.30A ) 7SUD (EM 3.60A ) |
| DBSNP | rs1805380 rs2287558 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:22442688, ECO:0000269|PubMed:32103174}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106, ECO:0000269|PubMed:32103174}. Chromosome {ECO:0000269|PubMed:22442688}. |
| Mouse PG classification | NA |
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