| Gene Information | |
|---|---|
| Gene Name | STUB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000103266 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UNE7 |
| Gene Card | STUB1 |
| Uniprot ID | Q9UNE7 |
| Pfam | PF18391; PF04564 |
| In ASD | no |
| Allosteric Prediction | yes (0.512277197) |
| Ortholog in Animals | Alpaca_ STUB1 ( ortholog_one2one ) Dog_ STUB1 ( ortholog_one2one ) GuineaPig_ STUB1 ( ortholog_one2one ) Macaque_ STUB1 ( ortholog_one2one ) Mouse_ Stub1 ( ortholog_one2one ) Pig_ STUB1 ( ortholog_one2one ) Rat_ Stub1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TTC1, TTC32, SUGT1, UNC45A, TTC4, TOMM34, SPAG1, SGTB, UNC45B, TOMM70, DNAAF4, TTC31, ST13, TTC12, STIP1, SPATA16, SGTA, RPAP3 |
| Tissue | NA |
| Tissue Specificity | Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highly expressed in skeletal muscle, heart, pancreas, brain and placenta (PubMed:10330192, PubMed:11435423). Detected in kidney, liver and lung (PubMed:10330192, PubMed:11435423). {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:17369820}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.008497(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4KBQ (X-ray 2.91A ) 6EFK (X-ray 1.50A ) 6NSV (X-ray 1.30A ) 7TB1 (X-ray 1.78A ) |
| DBSNP | rs690016544 rs587777347 rs587777346 rs587777344 rs587777341 rs146251364 rs587777342 rs587777340 rs587777345 rs587777343 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10330192, ECO:0000269|PubMed:17369820, ECO:0000269|PubMed:23973223}. Nucleus {ECO:0000269|PubMed:23973223}. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg). {ECO:0000269|PubMed:23973223}. |
| Mouse PG classification | HPG |
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