Gene Information
Gene NameCPSF6
OrganismHomo sapiens (Human)
Gene Length551
Protein NamesCleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000111605 )
Evolutionary StageEumetazoa
AlphaFoldDBQ16630
Gene CardCPSF6
Uniprot IDQ16630
PfamPF00076
In ASDno
Allosteric Predictionno (-0.808039801)
Ortholog in AnimalsAlpaca_ CPSF6 ( ortholog_one2one )
GuineaPig_ CPSF6 ( ortholog_one2one )
Macaque_ CPSF6 ( ortholog_one2one )
Mouse_ Cpsf6 ( ortholog_one2one )
Pig_ CPSF6 ( ortholog_one2one )
Rat_ Cpsf6 ( ortholog_one2one )
Rabbit_ CPSF6 ( ortholog_one2one )
OhnologsCPSF7
ParalogsCPSF7
TissueNA
Tissue SpecificityNA
Pharmacological Animal Models0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);0.021053(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3P5T  (X-ray  2.70A  )  3P6Y  (X-ray  2.90A  )  3Q2S  (X-ray  2.90A  )  3Q2T  (X-ray  3.06A  )  4B4N  (X-ray  1.81A  )  4U0A  (X-ray  2.05A  )  4U0B  (X-ray  2.80A  )  4WYM  (X-ray  2.60A  )  6AY9  (X-ray  2.50A  )  6GX9  (X-ray  2.70A  )  7ZUD  (X-ray  2.93A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:20695905, ECO:0000269|PubMed:30916345, ECO:0000269|PubMed:9659921}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17267687}. Nucleus speckle {ECO:0000269|PubMed:17267687}. Cytoplasm {ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:30916345}. Note=Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). Colocalizes with PSPC1 in punctate subnuclear structures often located adjacent to nuclear speckles, called paraspeckles, and corresponding to interchromatin granules-associated zones (IGAZs) (PubMed:17267687). Distribution in speckles and paraspeckles varies during the cell cycle (PubMed:17267687). Associates at sites of active transcription on nascent perichromatin fibrils (PFs) and perichromatin granules (PubMed:17267687). Nuclear import is mediated via interaction with TNPO3 independently of CPSF6 phosphorylation status (PubMed:30916345). {ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:17267687, ECO:0000269|PubMed:19864460, ECO:0000269|PubMed:30916345}.
Mouse PG classificationNA
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