| Gene Information | |
|---|---|
| Gene Name | XPO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1071 |
| Protein Names | Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) |
| Target Name | exportin-1 |
| Target Type | Clinical trial target |
| Gene Age | 1934 ( ENSG00000082898 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O14980 |
| Gene Card | XPO1 |
| Uniprot ID | O14980 |
| Pfam | PF08767; PF18777; PF18784; PF18787; PF03810; PF08389 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999904894) |
| Ortholog in Animals | Alpaca_ XPO1 ( ortholog_one2one ) Dog_ XPO1 ( ortholog_one2one ) GuineaPig_ XPO1 ( ortholog_one2one ) Macaque_ XPO1 ( ortholog_one2one ) Mouse_ Xpo1 ( ortholog_one2one ) Pig_ XPO1 ( ortholog_one2one ) Rat_ Xpo1 ( ortholog_one2one ) Rabbit_ XPO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XPO5 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes. Not expressed in the kidney. {ECO:0000269|PubMed:9049309, ECO:0000269|PubMed:9368044}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1W9C (X-ray 2.30A ) 2L1L (NMR - ) 3GB8 (X-ray 2.90A ) 4BSM (X-ray 4.50A ) 4BSN (X-ray 4.10A ) 5DIS (X-ray 2.85A ) 6TVO (X-ray 3.20A ) 7B51 (X-ray 2.58A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm. |
| Mouse PG classification | NA |
| click here to return to the previous page | |