| Gene Information | |
|---|---|
| Gene Name | CYP2B6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 491 |
| Protein Names | Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1) |
| Target Name | cytochrome p450 2b6 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000197408 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P20813 |
| Gene Card | CYP2B6 |
| Uniprot ID | P20813 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | yes (0.979644699) |
| Ortholog in Animals | Alpaca_ CYP2B6 ( ortholog_one2one ) Dog_ CYP2B6 ( ortholog_one2one ) GuineaPig_ CYP2B6 ( ortholog_one2one ) Macaque_ CYP2B6 ( ortholog_one2many ) Pig_ CYP2B6B ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CYP2S1, CYP2W1, CYP2D6, CYP2C18, CYP2C9, CYP2C19, CYP2C8, CYP2U1, CYP2A6, CYP2A7, CYP2A13, CYP2F1, CYP2R1, CYP2E1, CYP2J2 |
| Tissue | liver |
| Tissue Specificity | Expressed in liver, lung and heart right ventricle. {ECO:0000269|PubMed:10768437}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3IBD (X-ray 2.00A ) 3QOA (X-ray 2.10A ) 3QU8 (X-ray 2.80A ) 3UA5 (X-ray 2.80A ) 4I91 (X-ray 2.00A ) 4RQL (X-ray 2.10A ) 4RRT (X-ray 2.20A ) 4ZV8 (X-ray 2.24A ) 5UAP (X-ray 2.03A ) 5UDA (X-ray 1.93A ) 5UEC (X-ray 2.27A ) 5UFG (X-ray 1.76A ) 5WBG (X-ray 2.99A ) |
| DBSNP | rs34883432 rs8192709 rs33973337 rs33980385 rs34284776 rs33926104 rs35303484 rs36060847 rs12721655 rs35773040 rs3826711 rs3745274 rs45482602 rs2279343 rs34277950 rs34698757 rs28399499 rs35979566 rs3211371 |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Mouse PG classification | NA |
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