| Gene Information | |
|---|---|
| Gene Name | XPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 273 |
| Protein Names | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000136936 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P23025 |
| Gene Card | XPA |
| Uniprot ID | P23025 |
| Pfam | PF05181; PF01286 |
| In ASD | no |
| Allosteric Prediction | yes (0.125813963) |
| Ortholog in Animals | Alpaca_ XPA ( ortholog_one2one ) Dog_ XPA ( ortholog_one2one ) GuineaPig_ XPA ( ortholog_one2one ) Macaque_ XPA ( ortholog_one2one ) Mouse_ Xpa ( ortholog_one2one ) Pig_ XPA ( ortholog_one2one ) Rat_ Xpa ( ortholog_one2one ) Rabbit_ XPA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in various cell lines and in skin fibroblasts. {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:8543191}. |
| Pharmacological Animal Models | 0.157501(Chimpanzee);NULL(Mouse);NULL(Rat);0.048000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1D4U (NMR - ) 1XPA (NMR - ) 2JNW (NMR - ) 6J44 (X-ray 2.06A ) 6LAE (X-ray 2.81A ) 6RO4 (EM 3.50A ) 7AD8 (EM 3.50A ) |
| DBSNP | rs10983315 rs104894131 rs1324310300 rs746617574 rs1805160 rs3176749 rs144725456 rs3176750 rs57519506 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:20304803}. |
| Mouse PG classification | LPG |
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