| Gene Information | |
|---|---|
| Gene Name | PARVB |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Beta-parvin (Affixin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000188677 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9HBI1 |
| Gene Card | PARVB |
| Uniprot ID | Q9HBI1 |
| Pfam | PF00307 |
| In ASD | no |
| Allosteric Prediction | no (-1.011409117) |
| Ortholog in Animals | Alpaca_ PARVB ( ortholog_one2one ) Dog_ PARVB ( ortholog_one2one ) GuineaPig_ PARVB ( ortholog_one2one ) Macaque_ PARVB ( ortholog_one2one ) Mouse_ Parvb ( ortholog_one2one ) Pig_ PARVB ( ortholog_one2one ) Rat_ Parvb ( ortholog_one2one ) |
| Ohnologs | PARVA |
| Paralogs | PARVA, PARVG |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in heart and skeletal muscle. {ECO:0000269|PubMed:11402068, ECO:0000269|PubMed:11722847}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4EDL (X-ray 2.10A ) 4EDM (X-ray 2.00A ) 4EDN (X-ray 2.90A ) |
| DBSNP | rs34476853 rs1983609 |
| Subcellular location [CC] | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia. |
| Mouse PG classification | NA |
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