| Gene Information | |
|---|---|
| Gene Name | XLS |
| Organism | Homo sapiens (Human) |
| Gene Length | 204 |
| Protein Names | Protein PAXX (Paralog of XRCC4 and XLF) (XRCC4-like small protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BUH6 |
| Gene Card | PAXX |
| Uniprot ID | Q9BUH6 |
| Pfam | PF15384 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3WTD (X-ray 2.35A ) 3WTF (X-ray 3.45A ) 4WJA (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504, ECO:0000269|PubMed:29144403}. Chromosome {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000269|PubMed:25574025, ECO:0000269|PubMed:25670504}.; Cytoplasm {ECO:0000269|PubMed:29144403}. Note=(Microbial infection) Upon infection by herpesvirus 1 (HSV-1), it is partially translocated into the cytoplasm in an HSV-1-dependent manner. {ECO:0000269|PubMed:29144403}. |
| Mouse PG classification | NA |
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