| Gene Information | |
|---|---|
| Gene Name | XLF |
| Organism | Homo sapiens (Human) |
| Gene Length | 299 |
| Protein Names | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H9Q4 |
| Gene Card | NHEJ1 |
| Uniprot ID | Q9H9Q4 |
| Pfam | PF09302 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:16439204}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2QM4 (X-ray 2.30A ) 2R9A (X-ray 2.50A ) 3Q4F (X-ray 5.50A ) 3RWR (X-ray 3.94A ) 3SR2 (X-ray 3.97A ) 3W03 (X-ray 8.49A ) 6ERG (X-ray 2.90A ) 6ERH (X-ray 2.80A ) 7LSY (EM 8.40A ) 7LT3 (EM 4.60A ) 7NFC (EM 4.14A ) 7NFE (EM 4.29A ) |
| DBSNP | rs34689457 rs118204451 rs1056296 rs118204452 rs35270667 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16439204, ECO:0000269|PubMed:16439205, ECO:0000269|PubMed:20558749}. Chromosome {ECO:0000269|PubMed:18064046, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:27437582}. Note=Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. {ECO:0000269|PubMed:18064046, ECO:0000269|PubMed:18644470, ECO:0000269|PubMed:27437582}. |
| Mouse PG classification | NA |
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