| Gene Information | |
|---|---|
| Gene Name | TLK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 772 |
| Protein Names | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) |
| Target Name | serine/threonine-protein kinase tousled-like 2 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000146872 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86UE8 |
| Gene Card | TLK2 |
| Uniprot ID | Q86UE8 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.220182222) |
| Ortholog in Animals | Alpaca_ TLK2 ( ortholog_one2one ) Dog_ TLK2 ( ortholog_one2one ) GuineaPig_ TLK2 ( ortholog_one2one ) Macaque_ TLK2 ( ortholog_one2one ) Mouse_ Tlk2 ( ortholog_one2one ) Pig_ TLK2 ( ortholog_one2one ) Rat_ Tlk2 ( ortholog_one2one ) Rabbit_ TLK2 ( ortholog_one2one ) |
| Ohnologs | TLK1 |
| Paralogs | TLK1, TTK |
| Tissue | NA |
| Tissue Specificity | Detected in placenta, fetal liver, kidney, pancreas, heart and skeletal muscle (PubMed:9427565). Highly expressed in testis (PubMed:9427565, PubMed:9662073). Detected in spleen, thymus, colon, ovary, small intestine, prostate and peripheral blood leukocytes (PubMed:9662073). Almost undetectable in liver and lung (PubMed:9662073). {ECO:0000269|PubMed:9427565, ECO:0000269|PubMed:9662073}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5O0Y (X-ray 2.86A ) 7LO0 (X-ray 2.71A ) |
| DBSNP | rs45550140 rs2598147 rs1555617262 rs1331331651 rs762409144 rs1555639254 rs1567948287 rs1567948262 rs1567959483 rs1567974030 rs1567995650 rs1283838287 rs1568006217 rs1568018905 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10455159, ECO:0000269|PubMed:29955062, ECO:0000269|PubMed:33323470, ECO:0000269|PubMed:9427565}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:33323470}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10455159, ECO:0000269|PubMed:33323470}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10455159}. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle (PubMed:10455159). Present in the perinuclear region at S phase and in the nucleus at late G2 (PubMed:10455159). {ECO:0000269|PubMed:10455159}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |