| Gene Information | |
|---|---|
| Gene Name | SENP8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 212 |
| Protein Names | Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000166192 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96LD8 |
| Gene Card | SENP8 |
| Uniprot ID | Q96LD8 |
| Pfam | PF02902 |
| In ASD | no |
| Allosteric Prediction | no (-0.999968906) |
| Ortholog in Animals | Alpaca_ SENP8 ( ortholog_one2one ) Dog_ SENP8 ( ortholog_one2one ) Macaque_ SENP8 ( ortholog_one2one ) Mouse_ Senp8 ( ortholog_one2one ) Pig_ SENP8 ( ortholog_one2one ) Rat_ Senp8 ( ortholog_one2one ) Rabbit_ SENP8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | FAM76A, FAM76B |
| Tissue | substantia.nigra |
| Tissue Specificity | Broadly expressed, with highest levels in kidney and pancreas. {ECO:0000269|PubMed:12730221}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1XT9 (X-ray 2.20A ) 2BKQ (X-ray 2.00A ) 2BKR (X-ray 1.90A ) |
| DBSNP | rs930871 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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