| Gene Information | |
|---|---|
| Gene Name | XIAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 497 |
| Protein Names | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) |
| Target Name | xiap messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 886 ( ENSG00000101966 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P98170 |
| Gene Card | XIAP |
| Uniprot ID | P98170 |
| Pfam | PF00653 |
| In ASD | no |
| Allosteric Prediction | yes (1.171307072) |
| Ortholog in Animals | Alpaca_ XIAP ( ortholog_one2one ) Alpaca_ XIAP ( ortholog_one2many ) Dog_ XIAP ( ortholog_one2one ) GuineaPig_ XIAP ( ortholog_one2one ) Macaque_ XIAP ( ortholog_one2one ) Mouse_ Xiap ( ortholog_one2one ) Pig_ XIAP ( ortholog_one2one ) Rat_ Xiap ( ortholog_one2one ) Rabbit_ XIAP ( ortholog_one2one ) |
| Ohnologs | BIRC3, BIRC2 |
| Paralogs | NAIP, BIRC2, BIRC3, BIRC7, NLRC4, BIRC6, BIRC5 |
| Tissue | NA |
| Tissue Specificity | Expressed in colonic crypts (at protein level) (PubMed:30389919). Ubiquitous, except peripheral blood leukocytes (PubMed:8654366). {ECO:0000269|PubMed:30389919, ECO:0000269|PubMed:8654366}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1C9Q (NMR - ) 1F9X (NMR - ) 1G3F (NMR - ) 1G73 (X-ray 2.00A ) 1I3O (X-ray 2.70A ) 1I4O (X-ray 2.40A ) 1I51 (X-ray 2.45A ) 1KMC (X-ray 2.90A ) 1NW9 (X-ray 2.40A ) 1TFQ (NMR - ) 1TFT (NMR - ) 2ECG (NMR - ) 2JK7 (X-ray 2.82A ) 2KNA (NMR - ) 2OPY (X-ray 2.80A ) 2OPZ (X-ray 3.00A ) 2POI (X-ray 1.80A ) 2POP (X-ray 3.10A ) 2QRA (X-ray 2.50A ) 2VSL (X-ray 2.10A ) 3CLX (X-ray 2.70A ) 3CM2 (X-ray 2.50A ) 3CM7 (X-ray 3.10A ) 3EYL (X-ray 3.00A ) 3G76 (X-ray 3.00A ) 3HL5 (X-ray 1.80A ) 3UW4 (X-ray 1.79A ) 3UW5 (X-ray 1.71A ) 4EC4 (X-ray 3.30A ) 4HY0 (X-ray 2.84A ) 4IC2 (X-ray 2.20A ) 4IC3 (X-ray 1.78A ) 4J3Y (X-ray 1.45A ) 4J44 (X-ray 1.30A ) 4J45 (X-ray 1.48A ) 4J46 (X-ray 1.42A ) 4J47 (X-ray 1.35A ) 4J48 (X-ray 2.10A ) 4KJU (X-ray 1.60A ) 4KJV (X-ray 1.70A ) 4KMP (X-ray 1.95A ) 4MTZ (X-ray 2.10A ) 4OXC (X-ray 2.90A ) 4WVS (X-ray 2.09A ) 4WVT (X-ray 1.96A ) 4WVU (X-ray 2.02A ) 5C0K (X-ray 2.20A ) 5C0L (X-ray 2.60A ) 5C3H (X-ray 2.65A ) 5C3K (X-ray 2.02A ) 5C7A (X-ray 2.36A ) 5C7B (X-ray 2.68A ) 5C7C (X-ray 2.32A ) 5C7D (X-ray 2.25A ) 5C83 (X-ray 2.33A ) 5C84 (X-ray 2.36A ) 5M6E (X-ray 2.32A ) 5M6F (X-ray 2.39A ) 5M6H (X-ray 2.50A ) 5M6L (X-ray 2.61A ) 5M6M (X-ray 2.37A ) 5O6T (X-ray 1.57A ) 5OQW (X-ray 2.31A ) 6EY2 (X-ray 2.70A ) 6GJW (X-ray 1.90A ) 6QCI (X-ray 2.30A ) |
| DBSNP | rs28382721 rs28382722 rs28382723 rs5956583 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization. |
| Mouse PG classification | NA |
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