| Gene Information | |
|---|---|
| Gene Name | XDH |
| Organism | Homo sapiens (Human) |
| Gene Length | 1333 |
| Protein Names | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] |
| Target Name | xanthine dehydrogenase/oxidase |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000158125 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P47989 |
| Gene Card | XDH |
| Uniprot ID | P47989 |
| Pfam | PF01315; PF03450; PF00941; PF00111; PF01799; PF02738; PF20256 |
| In ASD | yes |
| Allosteric Prediction | yes (1.076543439) |
| Ortholog in Animals | Alpaca_ XDH ( ortholog_one2one ) Dog_ XDH ( ortholog_one2one ) GuineaPig_ XDH ( ortholog_one2one ) Macaque_ XDH ( ortholog_one2one ) Mouse_ Xdh ( ortholog_one2one ) Pig_ XDH ( ortholog_one2one ) Rat_ Xdh ( ortholog_one2one ) Rabbit_ XDH ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AOX1 |
| Tissue | duodenum, liver, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Detected in milk (at protein level). {ECO:0000269|Ref.12}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CKJ (X-ray 3.59A ) 2E1Q (X-ray 2.60A ) |
| DBSNP | rs45447191 rs72549369 rs45523133 rs45469499 rs34929837 rs45577338 rs45491693 rs45442092 rs45442398 rs45448694 rs17323225 rs17011368 rs775646772 rs669884 rs45619033 rs45547640 rs1042036 rs45624433 rs45564939 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Secreted. |
| Mouse PG classification | HPG |
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