| Gene Information | |
|---|---|
| Gene Name | ST14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 855 |
| Protein Names | Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein) |
| Target Name | suppressor of tumorigenicity 14 protein |
| Target Type | Patented-recorded target |
| Gene Age | 680 ( ENSG00000149418 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5Y6 |
| Gene Card | ST14 |
| Uniprot ID | Q9Y5Y6 |
| Pfam | PF00431; PF00057; PF01390; PF00089 |
| In ASD | no |
| Allosteric Prediction | yes (0.095389445) |
| Ortholog in Animals | Alpaca_ ST14 ( ortholog_one2one ) Dog_ ST14 ( ortholog_one2one ) GuineaPig_ ST14 ( ortholog_one2one ) Macaque_ ST14 ( ortholog_one2one ) Mouse_ St14 ( ortholog_one2one ) Pig_ ST14 ( ortholog_one2one ) Rat_ St14 ( ortholog_one2one ) Rabbit_ ST14 ( ortholog_one2one ) |
| Ohnologs | HPN, TMPRSS15, TMPRSS2, TMPRSS6, TMPRSS7 |
| Paralogs | TMPRSS15, TMPRSS6, HPN, TMPRSS11E, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1EAW (X-ray 2.93A ) 1EAX (X-ray 1.30A ) 2GV6 (X-ray 2.10A ) 2GV7 (X-ray 2.20A ) 3BN9 (X-ray 2.17A ) 3NCL (X-ray 1.19A ) 3NPS (X-ray 1.50A ) 3P8F (X-ray 2.00A ) 3P8G (X-ray 1.20A ) 3SO3 (X-ray 2.10A ) 4IS5 (X-ray 1.48A ) 4ISL (X-ray 2.29A ) 4ISN (X-ray 2.45A ) 4ISO (X-ray 2.01A ) 4JYT (X-ray 2.00A ) 4JZ1 (X-ray 1.90A ) 4JZI (X-ray 2.00A ) 4O97 (X-ray 2.20A ) 4O9V (X-ray 1.90A ) 4R0I (X-ray 1.90A ) 5LYO (X-ray 2.50A ) 6N4T (X-ray 1.95A ) 6T9T (X-ray 1.69A ) |
| DBSNP | rs7126904 rs17667603 rs137852931 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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