| Gene Information | |
|---|---|
| Gene Name | WWP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 922 |
| Protein Names | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) |
| Target Name | wwp1 messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 1488 ( ENSG00000123124 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H0M0 |
| Gene Card | WWP1 |
| Uniprot ID | Q9H0M0 |
| Pfam | PF00168; PF00632; PF00397 |
| In ASD | no |
| Allosteric Prediction | no (-0.268629158) |
| Ortholog in Animals | Alpaca_ WWP1 ( ortholog_one2one ) Dog_ WWP1 ( ortholog_one2one ) GuineaPig_ WWP1 ( ortholog_one2one ) Macaque_ WWP1 ( ortholog_one2one ) Mouse_ Wwp1 ( ortholog_one2one ) Pig_ WWP1 ( ortholog_one2one ) Rat_ Wwp1 ( ortholog_one2one ) Rabbit_ WWP1 ( ortholog_one2one ) |
| Ohnologs | ITCH, WWP2 |
| Paralogs | HERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, UBE3A, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6 |
| Tissue | NA |
| Tissue Specificity | Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. {ECO:0000269|PubMed:11779188, ECO:0000269|PubMed:9647693}. |
| Pharmacological Animal Models | 0.014666(Chimpanzee);0.032468(Mouse);0.001284(Rat);0.005882(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ND7 (X-ray 2.10A ) 2OP7 (NMR - ) 5HPS (X-ray 2.05A ) 5HPT (X-ray 2.84A ) 6J1X (X-ray 2.30A ) 6J1Y (X-ray 2.55A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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