| Gene Information | |
|---|---|
| Gene Name | WWOX |
| Organism | Homo sapiens (Human) |
| Gene Length | 414 |
| Protein Names | WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000186153 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NZC7 |
| Gene Card | WWOX |
| Uniprot ID | Q9NZC7 |
| Pfam | PF00106; PF00397 |
| In ASD | no |
| Allosteric Prediction | yes (0.185759091) |
| Ortholog in Animals | Alpaca_ WWOX ( ortholog_one2one ) Dog_ WWOX ( ortholog_one2one ) GuineaPig_ WWOX ( ortholog_one2one ) Macaque_ WWOX ( ortholog_one2one ) Mouse_ Wwox ( ortholog_one2one ) Pig_ WWOX ( ortholog_one2one ) Rat_ Wwox ( ortholog_one2one ) Rabbit_ WWOX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. {ECO:0000269|PubMed:10786676, ECO:0000269|PubMed:11719429}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1WMV (NMR - ) |
| DBSNP | rs730880292 rs587777128 rs144601717 rs114755364 rs141361080 rs11545029 rs7201683 rs186745328 rs3764340 rs119487098 rs73572838 rs587777127 rs77067228 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}. Nucleus {ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:15064722, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691}. Mitochondrion {ECO:0000269|PubMed:14695174}. Golgi apparatus {ECO:0000305}. Note=Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691}. |
| Mouse PG classification | LPG |
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