| Gene Information | |
|---|---|
| Gene Name | RPS6KA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 802 |
| Protein Names | Ribosomal protein S6 kinase alpha-5 (S6K-alpha-5) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 5) (Nuclear mitogen- and stress-activated protein kinase 1) (RSK-like protein kinase) (RSKL) |
| Target Name | ribosomal protein s6 kinase alpha-5 |
| Target Type | Patented-recorded target |
| Gene Age | 645 ( ENSG00000100784 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75582 |
| Gene Card | RPS6KA5 |
| Uniprot ID | O75582 |
| Pfam | PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | yes (0.325880677) |
| Ortholog in Animals | Alpaca_ RPS6KA5 ( ortholog_one2one ) Dog_ RPS6KA5 ( ortholog_one2one ) GuineaPig_ RPS6KA5 ( ortholog_one2one ) Macaque_ RPS6KA5 ( ortholog_one2one ) Mouse_ Rps6ka5 ( ortholog_one2one ) Pig_ RPS6KA5 ( ortholog_one2one ) Rat_ Rps6ka5 ( ortholog_one2one ) Rabbit_ RPS6KA5 ( ortholog_one2one ) |
| Ohnologs | RPS6KA4 |
| Paralogs | RPS6KA1, RPS6KB1, RPS6KA3, RPS6KA2, RPS6KB2, RPS6KA4, RPS6KA6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver. {ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9873047}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1VZO (X-ray 1.80A ) 3KN5 (X-ray 2.40A ) 3KN6 (X-ray 2.00A ) 7UP4 (X-ray 3.00A ) 7UP5 (X-ray 2.80A ) 7UP6 (X-ray 2.60A ) 7UP7 (X-ray 2.80A ) 7UP8 (X-ray 2.90A ) |
| DBSNP | rs34699345 rs55911249 rs34604933 rs55968863 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Predominantly nuclear. Exported into cytoplasm in response to glucocorticoid. |
| Mouse PG classification | NA |
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