| Gene Information | |
|---|---|
| Gene Name | WTX |
| Organism | Homo sapiens (Human) |
| Gene Length | 1135 |
| Protein Names | APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q5JTC6 |
| Gene Card | AMER1 |
| Uniprot ID | Q5JTC6 |
| Pfam | PF09422 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in fetal and adult kidney, brain and spleen. {ECO:0000269|PubMed:19416806}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YJE (X-ray 1.90A ) 4YJL (X-ray 2.10A ) 4YK6 (X-ray 1.70A ) |
| DBSNP | rs34677493 rs376626895 rs35718712 rs138948924 |
| Subcellular location [CC] | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2. |
| Mouse PG classification | NA |
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