| Gene Information | |
|---|---|
| Gene Name | WTAP |
| Organism | Homo sapiens (Human) |
| Gene Length | 396 |
| Protein Names | Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146457 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15007 |
| Gene Card | WTAP |
| Uniprot ID | Q15007 |
| Pfam | PF17098 |
| In ASD | no |
| Allosteric Prediction | no (-0.491256254) |
| Ortholog in Animals | Alpaca_ WTAP ( ortholog_one2one ) Dog_ WTAP ( ortholog_one2one ) GuineaPig_ WTAP ( ortholog_one2one ) Macaque_ WTAP ( ortholog_one2one ) Mouse_ Wtap ( ortholog_one2one ) Pig_ WTAP ( ortholog_one2one ) Rat_ Wtap ( ortholog_one2one ) Rabbit_ WTAP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:11001926}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003298(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35059844 |
| Subcellular location [CC] | Nucleus speckle {ECO:0000269|PubMed:24407421}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11001926, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:26458103}. Cytoplasm {ECO:0000250|UniProtKB:Q9ER69}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:Q9ER69}. |
| Mouse PG classification | NA |
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