| Gene Information | |
|---|---|
| Gene Name | TFPI |
| Organism | Homo sapiens (Human) |
| Gene Length | 304 |
| Protein Names | Tissue factor pathway inhibitor (TFPI) (Extrinsic pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI) |
| Target Name | tissue factor pathway inhibitor |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000003436 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P10646 |
| Gene Card | TFPI |
| Uniprot ID | P10646 |
| Pfam | PF00014 |
| In ASD | no |
| Allosteric Prediction | yes (0.745947201) |
| Ortholog in Animals | Alpaca_ TFPI ( ortholog_one2one ) Dog_ TFPI ( ortholog_one2one ) Macaque_ TFPI ( ortholog_one2one ) Mouse_ Tfpi ( ortholog_one2one ) Pig_ TFPI ( ortholog_one2one ) Rat_ Tfpi ( ortholog_one2one ) Rabbit_ TFPI ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPINT4, EPPIN, WFIKKN1, KIAA0319, SPINT1, TFPI2, AMBP, SPINT2, WFIKKN2, WFDC8, LRP11, KIAA0319L, WFDC6 |
| Tissue | NA |
| Tissue Specificity | Mostly in endothelial cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ADZ (NMR - ) 1IRH (NMR - ) 1TFX (X-ray 2.60A ) 4BQD (X-ray 2.48A ) 4DTG (X-ray 1.80A ) 5NMV (X-ray 1.65A ) 6BX8 (X-ray 1.98A ) 7V1N (EM 3.20A ) |
| DBSNP | rs5940 |
| Subcellular location [CC] | [Isoform Alpha]: Secreted.; [Isoform Beta]: Microsome membrane {ECO:0000269|PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:22144186}. |
| Mouse PG classification | NA |
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