| Gene Information | |
|---|---|
| Gene Name | WRN |
| Organism | Homo sapiens (Human) |
| Gene Length | 1432 |
| Protein Names | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 3.6.4.12)] |
| Target Name | werner syndrome atp-dependent helicase |
| Target Type | Literature-reported target |
| Gene Age | 1488 ( ENSG00000165392 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q14191 |
| Gene Card | WRN |
| Uniprot ID | Q14191 |
| Pfam | PF00270; PF01612; PF00271; PF00570; PF14493; PF16124; PF09382 |
| In ASD | no |
| Allosteric Prediction | yes (0.619961271) |
| Ortholog in Animals | Alpaca_ WRN ( ortholog_one2one ) Dog_ WRN ( ortholog_one2one ) GuineaPig_ WRN ( ortholog_one2one ) Macaque_ WRN ( ortholog_one2one ) Mouse_ Wrn ( ortholog_one2one ) Pig_ WRN ( ortholog_one2one ) Rat_ Wrn ( ortholog_one2one ) Rabbit_ WRN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RECQL5, RECQL4, BLM, RECQL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.043303(Mouse);0.012381(Rat);0.093827(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2AXL (NMR - ) 2DGZ (NMR - ) 2E1E (X-ray 2.30A ) 2E1F (X-ray 2.00A ) 2FBT (X-ray 2.05A ) 2FBV (X-ray 2.40A ) 2FBX (X-ray 2.20A ) 2FBY (X-ray 2.00A ) 2FC0 (X-ray 2.00A ) 3AAF (X-ray 1.90A ) 6TYV (X-ray 1.93A ) 6YHR (X-ray 2.20A ) |
| DBSNP | rs34477820 rs2230009 rs387906337 rs267607008 rs367991517 rs148229804 rs1800390 rs4987237 rs11574222 rs4987238 rs1800391 rs11574240 rs11574250 rs11574289 rs34560788 rs3087425 rs11574323 rs1801195 rs3087414 rs11574358 rs139323683 rs746648510 rs11574395 rs1346044 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:23180761, ECO:0000269|PubMed:9618508}. Nucleus {ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:19652551, ECO:0000269|PubMed:23180761}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21639834}. Chromosome {ECO:0000269|PubMed:27063109}. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation (PubMed:21639834). Localizes to DNA damage sites (PubMed:27063109). {ECO:0000269|PubMed:21639834, ECO:0000269|PubMed:27063109}. |
| Mouse PG classification | LPG |
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