| Gene Information | |
|---|---|
| Gene Name | WRAP53 |
| Organism | Homo sapiens (Human) |
| Gene Length | 548 |
| Protein Names | Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000141499 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BUR4 |
| Gene Card | WRAP53 |
| Uniprot ID | Q9BUR4 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.674210225) |
| Ortholog in Animals | Alpaca_ WRAP53 ( ortholog_one2one ) Dog_ WRAP53 ( ortholog_one2one ) GuineaPig_ WRAP53 ( ortholog_one2one ) Macaque_ WRAP53 ( ortholog_one2one ) Mouse_ Wrap53 ( ortholog_one2one ) Pig_ WRAP53 ( ortholog_one2one ) Rat_ Wrap53 ( ortholog_one2one ) Rabbit_ WRAP53 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues and cell lines examined. {ECO:0000269|PubMed:19250907}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BGB (EM 3.39A ) 7TRC (EM 3.30A ) 7V9A (EM 3.94A ) |
| DBSNP | rs17880282 rs2287499 rs34067256 rs281865547 rs35762939 rs281865549 rs281865548 rs281865550 rs35123152 rs7640 |
| Subcellular location [CC] | Nucleus, Cajal body {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19285445, ECO:0000269|PubMed:21072240, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:24318571, ECO:0000269|PubMed:26170453}. Chromosome, telomere {ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:29804836}. Chromosome {ECO:0000269|PubMed:25512560, ECO:0000269|PubMed:26734725, ECO:0000269|PubMed:27715493}. Note=Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725, PubMed:27715493). {ECO:0000269|PubMed:26170453, ECO:0000269|PubMed:26734725, ECO:0000269|PubMed:27715493}. |
| Mouse PG classification | NA |
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