| Gene Information | |
|---|---|
| Gene Name | WNK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1243 |
| Protein Names | Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000126562 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96J92 |
| Gene Card | WNK4 |
| Uniprot ID | Q96J92 |
| Pfam | PF12202; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.417535393) |
| Ortholog in Animals | Alpaca_ WNK4 ( ortholog_one2one ) Dog_ WNK4 ( ortholog_one2one ) GuineaPig_ WNK4 ( ortholog_one2one ) Macaque_ WNK4 ( ortholog_one2one ) Mouse_ Wnk4 ( ortholog_one2one ) Pig_ WNK4 ( ortholog_one2one ) Rat_ Vps25 ( ortholog_one2one ) Rabbit_ WNK4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRBP1, NRBP2, WNK1, WNK3, WNK2, DSTYK |
| Tissue | colon, kidney, prostate |
| Tissue Specificity | Expressed in kidney, colon and skin. {ECO:0000269|PubMed:11571656}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.054545(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2V3S (X-ray 1.70A ) 4CH9 (X-ray 1.84A ) 4CHB (X-ray 1.56A ) |
| DBSNP | rs137853093 rs137853094 rs137853092 rs55781437 rs9896991 rs2290041 rs137853095 |
| Subcellular location [CC] | Cell junction, tight junction {ECO:0000250|UniProtKB:Q80UE6}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex. {ECO:0000250|UniProtKB:Q80UE6}. |
| Mouse PG classification | HPG |
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