| Gene Information | |
|---|---|
| Gene Name | WNK3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1800 |
| Protein Names | Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000196632 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BYP7 |
| Gene Card | WNK3 |
| Uniprot ID | Q9BYP7 |
| Pfam | PF12202; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.410231758) |
| Ortholog in Animals | Alpaca_ WNK3 ( ortholog_one2one ) GuineaPig_ WNK3 ( ortholog_one2one ) Macaque_ WNK3 ( ortholog_one2one ) Mouse_ Wnk3 ( ortholog_one2one ) Pig_ WNK3 ( ortholog_one2one ) Rat_ Wnk3 ( ortholog_one2one ) Rabbit_ WNK3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRBP1, NRBP2, WNK4, WNK1, WNK2, DSTYK |
| Tissue | testis, liver |
| Tissue Specificity | Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific. {ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:15194194, ECO:0000269|PubMed:16275913}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5NKP (X-ray 2.80A ) 5O1V (X-ray 1.72A ) 5O21 (X-ray 2.06A ) 5O23 (X-ray 2.25A ) 5O26 (X-ray 2.38A ) 5O2B (X-ray 2.04A ) 5O2C (X-ray 2.40A ) |
| DBSNP | rs56077971 rs56404148 rs55903619 rs55879434 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16501604}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |