| Gene Information | |
|---|---|
| Gene Name | WNK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2382 |
| Protein Names | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000060237 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H4A3 |
| Gene Card | WNK1 |
| Uniprot ID | Q9H4A3 |
| Pfam | PF12202; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.74262283) |
| Ortholog in Animals | Alpaca_ WNK1 ( ortholog_one2one ) Dog_ WNK1 ( ortholog_one2one ) GuineaPig_ WNK1 ( ortholog_one2one ) Macaque_ WNK1 ( ortholog_one2one ) Mouse_ Wnk1 ( ortholog_one2one ) Pig_ WNK1 ( ortholog_one2one ) Rat_ Wnk1 ( ortholog_one2one ) Rabbit_ WNK1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRBP1, NRBP2, WNK4, WNK3, WNK2, DSTYK |
| Tissue | kidney |
| Tissue Specificity | Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific and specifically expressed in the distal convoluted tubule (DCT) and connecting tubule (CNT) of the nephron. {ECO:0000269|PubMed:10660600, ECO:0000269|PubMed:11571656, ECO:0000269|PubMed:14645531, ECO:0000269|PubMed:22701532}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4PWN (X-ray 1.84A ) 5TF9 (X-ray 2.50A ) 5WDY (X-ray 2.46A ) 5WE8 (X-ray 2.01A ) 6FBK (X-ray 1.74A ) |
| DBSNP | rs11554421 rs34880640 rs34728563 rs34408667 rs2286007 rs11833299 rs56015776 rs956868 rs7955371 rs56351358 rs12828016 rs17755373 rs36083875 rs56262445 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10660600}. |
| Mouse PG classification | LPG |
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