| Gene Information | |
|---|---|
| Gene Name | WLS |
| Organism | Homo sapiens (Human) |
| Gene Length | 541 |
| Protein Names | Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000116729 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q5T9L3 |
| Gene Card | WLS |
| Uniprot ID | Q5T9L3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.708943604) |
| Ortholog in Animals | Alpaca_ WLS ( ortholog_one2one ) Dog_ WLS ( ortholog_one2one ) GuineaPig_ WLS ( ortholog_one2one ) Macaque_ WLS ( ortholog_one2one ) Mouse_ Wls ( ortholog_one2one ) Pig_ WLS ( ortholog_one2one ) Rat_ Wls ( ortholog_one2one ) Rabbit_ WLS ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7DRT (EM 2.20A ) 7KC4 (EM 3.19A ) |
| DBSNP | rs983034 rs985347096 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cell membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269|PubMed:18160347}. |
| Mouse PG classification | NA |
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