| Gene Information | |
|---|---|
| Gene Name | ALKBH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 286 |
| Protein Names | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (EC 1.14.11.33) (EC 1.14.11.54) (Alkylated DNA repair protein alkB homolog 3) (hABH3) (DEPC-1) (Prostate cancer antigen 1) |
| Target Name | alpha-ketoglutarate-dependent dioxygenase alkb homolog 3 |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000166199 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96Q83 |
| Gene Card | ALKBH3 |
| Uniprot ID | Q96Q83 |
| Pfam | PF13532 |
| In ASD | no |
| Allosteric Prediction | no (-0.436367456) |
| Ortholog in Animals | Alpaca_ ALKBH3 ( ortholog_one2one ) GuineaPig_ ALKBH3 ( ortholog_one2one ) Macaque_ ALKBH3 ( ortholog_one2one ) Mouse_ Alkbh3 ( ortholog_one2one ) Pig_ ALKBH3 ( ortholog_one2one ) Rat_ Alkbh3 ( ortholog_one2one ) Rabbit_ ALKBH3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:17979886}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005985(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IUW (X-ray 1.50A ) |
| DBSNP | rs2271815 rs1130290 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:29144457}. Cytoplasm {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:17979886}. Note=Colocalizes with ASCC2 and ASCC3 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage (PubMed:29144457). Predominantly localizes to the nucleus. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:29144457}. |
| Mouse PG classification | NA |
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