| Gene Information | |
|---|---|
| Gene Name | WIPI2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 454 |
| Protein Names | WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157954 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y4P8 |
| Gene Card | WIPI2 |
| Uniprot ID | Q9Y4P8 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.012089979) |
| Ortholog in Animals | Alpaca_ WIPI2 ( ortholog_one2many ) Dog_ WIPI2 ( ortholog_one2one ) GuineaPig_ WIPI2 ( ortholog_one2one ) Macaque_ WIPI2 ( ortholog_one2one ) Mouse_ Wipi2 ( ortholog_one2one ) Pig_ WIPI2 ( ortholog_one2one ) Rat_ Wipi2 ( ortholog_one2one ) Rabbit_ WIPI2 ( ortholog_one2one ) |
| Ohnologs | WIPI1 |
| Paralogs | WDR45B, WIPI1, WDR45 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors. {ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20505359}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.03(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7MU2 (X-ray 1.85A ) |
| DBSNP | rs756429763 |
| Subcellular location [CC] | Preautophagosomal structure membrane {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:23916833, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:28890335, ECO:0000269|PubMed:33499712}; Peripheral membrane protein {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}; Cytoplasmic side {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269|PubMed:24954904}. |
| Mouse PG classification | NA |
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