| Gene Information | |
|---|---|
| Gene Name | WIPF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 503 |
| Protein Names | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000115935 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43516 |
| Gene Card | WIPF1 |
| Uniprot ID | O43516 |
| Pfam | PF02205 |
| In ASD | no |
| Allosteric Prediction | no (-0.437758871) |
| Ortholog in Animals | Alpaca_ WIPF1 ( ortholog_one2one ) Dog_ WIPF1 ( ortholog_one2one ) Macaque_ WIPF1 ( ortholog_one2one ) Mouse_ Wipf1 ( ortholog_one2one ) Rat_ Wipf1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WIPF3, WIPF2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis. {ECO:0000269|PubMed:9405671}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A41 (X-ray 2.60A ) |
| DBSNP | rs4972450 |
| Subcellular location [CC] | Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000269|PubMed:19910490}. Note=Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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