| Gene Information | |
|---|---|
| Gene Name | CEMIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 1361 |
| Protein Names | Cell migration-inducing and hyaluronan-binding protein (EC 3.2.1.35) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000103888 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8WUJ3 |
| Gene Card | CEMIP |
| Uniprot ID | Q8WUJ3 |
| Pfam | PF10162; PF15711; PF13330 |
| In ASD | no |
| Allosteric Prediction | yes (0.000686016) |
| Ortholog in Animals | Alpaca_ CEMIP ( ortholog_one2one ) Dog_ CEMIP ( ortholog_one2one ) GuineaPig_ CEMIP ( ortholog_one2one ) Macaque_ CEMIP ( ortholog_one2one ) Mouse_ Cemip ( ortholog_one2one ) Pig_ CEMIP ( ortholog_one2one ) Rat_ Cemip ( ortholog_one2one ) Rabbit_ CEMIP ( ortholog_one2one ) |
| Ohnologs | CEMIP2 |
| Paralogs | CEMIP2 |
| Tissue | NA |
| Tissue Specificity | Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue. {ECO:0000269|PubMed:10574462, ECO:0000269|PubMed:12471561, ECO:0000269|PubMed:16157444, ECO:0000269|PubMed:19434458, ECO:0000269|PubMed:21772334, ECO:0000269|PubMed:22970280, ECO:0000269|PubMed:23936024, ECO:0000269|PubMed:23990668}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs368854657 rs144446375 rs12441101 rs996035812 rs751807711 rs16972583 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas. |
| Mouse PG classification | NA |
| click here to return to the previous page | |