| Gene Information | |
|---|---|
| Gene Name | CRAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 626 |
| Protein Names | Carnitine O-acetyltransferase (Carnitine acetylase) (EC 2.3.1.137) (EC 2.3.1.7) (Carnitine acetyltransferase) (CAT) (CrAT) |
| Target Name | carnitine acyltransferase |
| Target Type | Discontinued target |
| Gene Age | 1292 ( ENSG00000095321 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P43155 |
| Gene Card | CRAT |
| Uniprot ID | P43155 |
| Pfam | PF00755 |
| In ASD | no |
| Allosteric Prediction | yes (0.331031217) |
| Ortholog in Animals | Alpaca_ CRAT ( ortholog_one2many ) Dog_ CRAT ( ortholog_one2one ) GuineaPig_ CRAT ( ortholog_one2one ) Macaque_ CRAT ( ortholog_one2one ) Mouse_ Crat ( ortholog_one2one ) Pig_ CRAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHAT, CROT, CPT1B, CPT2, CPT1C, CPT1A |
| Tissue | NA |
| Tissue Specificity | Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NM8 (X-ray 1.60A ) 1S5O (X-ray 1.80A ) |
| DBSNP | rs138665095 rs3118635 rs17459086 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000305}. Peroxisome {ECO:0000305}. Mitochondrion inner membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Matrix side {ECO:0000305}.; [Isoform 1]: Mitochondrion {ECO:0000305|PubMed:23485643}.; [Isoform 2]: Peroxisome {ECO:0000305|PubMed:23485643}. |
| Mouse PG classification | NA |
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