| Gene Information | |
|---|---|
| Gene Name | WFS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 890 |
| Protein Names | Wolframin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000109501 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O76024 |
| Gene Card | WFS1 |
| Uniprot ID | O76024 |
| Pfam | PF20053; PF19913; PF19914; PF20023 |
| In ASD | no |
| Allosteric Prediction | no (-0.014989152) |
| Ortholog in Animals | Alpaca_ WFS1 ( ortholog_one2one ) GuineaPig_ WFS1 ( ortholog_one2one ) Macaque_ WFS1 ( ortholog_one2one ) Mouse_ Wfs1 ( ortholog_one2one ) Pig_ WFS1 ( ortholog_one2one ) Rat_ Wfs1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs34653805 rs369671890 rs145639028 rs372249044 rs148953711 rs758281375 rs41264699 rs746923441 rs369795224 rs1801212 rs147974629 rs1801208 rs113446173 rs398123066 rs28937892 rs199946797 rs55814513 rs1805069 rs2230720 rs734312 rs71530910 rs104893882 rs201064551 rs1402999203 rs200672755 rs387906930 rs142668478 rs754373473 rs28937891 rs28937894 rs1323852277 rs200099217 rs28937893 rs1805070 rs28937890 rs71532864 rs147834269 rs141328044 rs387906931 rs746922325 rs35932623 rs104893883 rs28937895 rs876657675 rs121912618 rs74315205 rs71532874 rs372855769 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:23035048}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:23035048}. Note=Co-localizes with ATP6V1A in the secretory granules in neuroblastoma cell lines. {ECO:0000269|PubMed:23035048}. |
| Mouse PG classification | LPG |
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