| Gene Information | |
|---|---|
| Gene Name | CHRNA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | Neuronal acetylcholine receptor subunit alpha-2 |
| Target Name | neuronal acetylcholine receptor alpha-2 |
| Target Type | Successful target |
| Gene Age | 454 ( ENSG00000120903 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15822 |
| Gene Card | CHRNA2 |
| Uniprot ID | Q15822 |
| Pfam | PF02931; PF02932 |
| In ASD | no |
| Allosteric Prediction | yes (1.11251422) |
| Ortholog in Animals | Alpaca_ CHRNA2 ( ortholog_one2one ) Dog_ CHRNA2 ( ortholog_one2one ) GuineaPig_ CHRNA2 ( ortholog_one2one ) Macaque_ CHRNA2 ( ortholog_one2one ) Mouse_ Chrna2 ( ortholog_one2one ) Pig_ CHRNA2 ( ortholog_one2one ) Rat_ Chrna2 ( ortholog_one2one ) Rabbit_ CHRNA2 ( ortholog_one2one ) |
| Ohnologs | CHRNA3, CHRNA4, CHRNB4, CHRNB2 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | prostate |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 5FJV (X-ray 3.20A ) |
| DBSNP | rs2472553 rs891398 rs104894063 rs1018084204 |
| Subcellular location [CC] | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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