| Gene Information | |
|---|---|
| Gene Name | CAP-1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 568 |
| Protein Names | TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13114 |
| Gene Card | TRAF3 |
| Uniprot ID | Q13114 |
| Pfam | PF02176 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.026667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FLK (X-ray 2.80A ) 1FLL (X-ray 3.50A ) 1KZZ (X-ray 3.50A ) 1L0A (X-ray 2.90A ) 1RF3 (X-ray 3.50A ) 1ZMS (X-ray 2.80A ) 2ECY (NMR - ) 2GKW (X-ray 2.70A ) |
| DBSNP | rs143813189 rs1131877 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:25847972, ECO:0000269|PubMed:34011520}. Endosome {ECO:0000250|UniProtKB:Q60803}. Mitochondrion {ECO:0000269|PubMed:32562145}. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Co-localized to mitochondria with TRIM35 (PubMed:32562145). {ECO:0000250|UniProtKB:Q60803, ECO:0000269|PubMed:32562145}. |
| Mouse PG classification | NA |
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