| Gene Information | |
|---|---|
| Gene Name | WEE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 646 |
| Protein Names | Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase) |
| Target Name | wee1-like protein kinase |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000166483 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P30291 |
| Gene Card | WEE1 |
| Uniprot ID | P30291 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.872886297) |
| Ortholog in Animals | Alpaca_ WEE1 ( ortholog_one2one ) Dog_ WEE1 ( ortholog_one2one ) GuineaPig_ WEE1 ( ortholog_one2one ) Macaque_ WEE1 ( ortholog_one2one ) Mouse_ Wee1 ( ortholog_one2one ) Pig_ WEE1 ( ortholog_one2one ) Rat_ Wee1 ( ortholog_one2one ) Rabbit_ WEE1 ( ortholog_one2one ) |
| Ohnologs | WEE2 |
| Paralogs | STK35, PKMYT1, EIF2AK3, EIF2AK4, WEE2, EIF2AK2, PDIK1L, EIF2AK1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.0375(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1X8B (X-ray 1.81A ) 2IN6 (X-ray 1.90A ) 2IO6 (X-ray 2.20A ) 2Z2W (X-ray 2.22A ) 3BI6 (X-ray 2.20A ) 3BIZ (X-ray 2.20A ) 3CQE (X-ray 2.50A ) 3CR0 (X-ray 2.30A ) 5V5Y (X-ray 1.90A ) 5VC3 (X-ray 1.97A ) 5VC4 (X-ray 2.10A ) 5VC5 (X-ray 1.93A ) 5VC6 (X-ray 2.00A ) 5VD2 (X-ray 2.05A ) 5VD4 (X-ray 2.02A ) 5VD5 (X-ray 2.05A ) 5VD7 (X-ray 2.08A ) 5VD8 (X-ray 1.85A ) 5VD9 (X-ray 1.87A ) 5VDA (X-ray 2.10A ) 7N3U (X-ray 2.65A ) |
| DBSNP | rs34412975 rs56411856 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | NA |
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