| Gene Information | |
|---|---|
| Gene Name | RIF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2472 |
| Protein Names | Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000080345 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q5UIP0 |
| Gene Card | RIF1 |
| Uniprot ID | Q5UIP0 |
| Pfam | PF12231 |
| In ASD | no |
| Allosteric Prediction | yes (0.095047118) |
| Ortholog in Animals | Alpaca_ RIF1 ( ortholog_one2one ) Dog_ RIF1 ( ortholog_one2one ) GuineaPig_ RIF1 ( ortholog_one2one ) Macaque_ RIF1 ( ortholog_one2one ) Mouse_ Rif1 ( ortholog_one2one ) Pig_ RIF1 ( ortholog_one2one ) Rat_ Rif1 ( ortholog_one2one ) Rabbit_ RIF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis. {ECO:0000269|PubMed:15583028}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.042857(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2444263 rs2123465 rs3732305 rs2444258 rs2444257 rs16830057 rs1065177 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15583028}. Chromosome {ECO:0000250|UniProtKB:Q6PR54}. Chromosome, telomere {ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15583028}. Note=Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs) (PubMed:15342490). Does not associate with normal telomere structures (PubMed:15342490, PubMed:15583028). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (PubMed:15583028). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028}. |
| Mouse PG classification | NA |
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