| Gene Information | |
|---|---|
| Gene Name | USP7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1102 |
| Protein Names | Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7) |
| Target Name | herpesvirus ubiquitin-specific protease |
| Target Type | Preclinical target |
| Gene Age | 1488 ( ENSG00000187555 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q93009 |
| Gene Card | USP7 |
| Uniprot ID | Q93009 |
| Pfam | PF00917; PF00443; PF14533; PF12436 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000053368) |
| Ortholog in Animals | Alpaca_ USP7 ( ortholog_one2one ) Dog_ USP7 ( ortholog_one2one ) GuineaPig_ USP7 ( ortholog_one2one ) Macaque_ USP7 ( ortholog_one2one ) Mouse_ Usp7 ( ortholog_one2one ) Pig_ USP7 ( ortholog_one2one ) Rat_ Usp7 ( ortholog_one2one ) Rabbit_ USP7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | USP11, USP20, USP4, USP5, USP42, USP14, USP29, USP25, USP48, USP2, USP47, USP40, USP3, USP1, USP34, USP8, USP21, USP24, USP38, USP32, USP6, USP31, USP50, USP13, USP43, USP17L4, USP17L11, USP17L27, USP17L22, USP17L30, USP17L17, USP17L26, USP17L25, USP17L12, USP17L10, USP17L28, USP17L1, USP17L5, USP17L24, USP17L21, USP17L3, USP17L29, USP17L18, USP17L13, USP17L15, USP17L7, USP17L23, USP17L2, USP17L20, USP17L8, USP17L19, USP35, USP45, USP33, USP49, USP51, USP19, USP15, USP28, USP9X, USP9Y, USP27X, USP44, USP18, USP30, USP10, USP22, USP26, USP16, USP37, USP36 |
| Tissue | NA |
| Tissue Specificity | Expressed in neural progenitor cells (at protein level) (PubMed:21258371). Widely expressed. Overexpressed in prostate cancer. {ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:21258371}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NB8 (X-ray 2.30A ) 1NBF (X-ray 2.30A ) 1YY6 (X-ray 1.70A ) 1YZE (X-ray 2.00A ) 2F1W (X-ray 1.65A ) 2F1X (X-ray 2.30A ) 2F1Y (X-ray 1.70A ) 2F1Z (X-ray 3.20A ) 2FOJ (X-ray 1.60A ) 2FOO (X-ray 2.20A ) 2FOP (X-ray 2.10A ) 2KVR (NMR - ) 2XXN (X-ray 1.60A ) 2YLM (X-ray 2.70A ) 3MQR (X-ray 1.80A ) 3MQS (X-ray 2.40A ) 4JJQ (X-ray 1.95A ) 4KG9 (X-ray 1.70A ) 4M5W (X-ray 2.24A ) 4M5X (X-ray 2.19A ) 4PYZ (X-ray 2.84A ) 4WPH (X-ray 2.92A ) 4WPI (X-ray 3.40A ) 4YOC (X-ray 2.92A ) 4YSI (X-ray 1.02A ) 4Z96 (X-ray 2.85A ) 4Z97 (X-ray 3.00A ) 5C56 (X-ray 2.69A ) 5C6D (X-ray 2.29A ) 5FWI (X-ray 3.40A ) 5GG4 (X-ray 3.11A ) 5J7T (X-ray 3.20A ) 5JTJ (X-ray 3.32A ) 5JTV (X-ray 3.31A ) 5KYB (X-ray 2.20A ) 5KYC (X-ray 1.43A ) 5KYD (X-ray 1.62A ) 5KYE (X-ray 1.97A ) 5KYF (X-ray 1.45A ) 5N9R (X-ray 2.23A ) 5N9T (X-ray 1.73A ) 5NGE (X-ray 2.35A ) 5NGF (X-ray 2.33A ) 5UQV (X-ray 2.84A ) 5UQX (X-ray 2.23A ) 5VS6 (X-ray 2.27A ) 5VSB (X-ray 1.85A ) 5VSK (X-ray 3.33A ) 5WHC (X-ray 2.55A ) 6F5H (X-ray 2.16A ) 6M1K (X-ray 2.25A ) 6P5L (X-ray 3.30A ) 6VN2 (X-ray 2.93A ) 6VN3 (X-ray 2.73A ) 6VN4 (X-ray 2.69A ) 6VN5 (X-ray 2.90A ) 6VN6 (X-ray 2.99A ) 7CM2 (X-ray 2.25A ) 7VIJ (X-ray 2.30A ) 7XPY (X-ray 2.35A ) |
| DBSNP | rs1555465642 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21258371, ECO:0000269|PubMed:23973222, ECO:0000269|PubMed:25283148, ECO:0000269|PubMed:26678539}. Cytoplasm {ECO:0000269|PubMed:25283148}. Nucleus, PML body {ECO:0000269|PubMed:9034339}. Chromosome {ECO:0000269|PubMed:20601937}. Note=Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies. |
| Mouse PG classification | NA |
| click here to return to the previous page | |