| Gene Information | |
|---|---|
| Gene Name | P2RY12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 342 |
| Protein Names | P2Y purinoceptor 12 (P2Y12) (ADP-glucose receptor) (ADPG-R) (P2T(AC)) (P2Y(AC)) (P2Y(cyc)) (P2Y12 platelet ADP receptor) (P2Y(ADP)) (SP1999) |
| Target Name | p2y purinoceptor 12 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000169313 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H244 |
| Gene Card | P2RY12 |
| Uniprot ID | Q9H244 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.12163322) |
| Ortholog in Animals | Alpaca_ P2RY12 ( ortholog_one2one ) Dog_ P2RY12 ( ortholog_one2one ) Macaque_ P2RY12 ( ortholog_one2one ) Mouse_ P2ry12 ( ortholog_one2one ) Pig_ P2RY12 ( ortholog_one2one ) Rat_ P2ry12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GPR34, GPR171, PTAFR, P2RY13, GPR87, P2RY14 |
| Tissue | cerebral.cortex |
| Tissue Specificity | Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. {ECO:0000269|PubMed:11104774, ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:11502873}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4NTJ (X-ray 2.62A ) 4PXZ (X-ray 2.50A ) 4PY0 (X-ray 3.10A ) |
| DBSNP | rs121917885 rs121917886 rs16846673 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}; Multi-pass membrane protein {ECO:0000269|PubMed:11196645, ECO:0000269|PubMed:12578987, ECO:0000269|PubMed:24670650, ECO:0000269|PubMed:24784220}. |
| Mouse PG classification | HPG |
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