| Gene Information | |
|---|---|
| Gene Name | DDX6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) |
| Target Name | probable atp-dependent rna helicase ddx6 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000110367 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P26196 |
| Gene Card | DDX6 |
| Uniprot ID | P26196 |
| Pfam | PF00270; PF00271 |
| In ASD | no |
| Allosteric Prediction | no (-0.127272707) |
| Ortholog in Animals | Alpaca_ DDX6 ( ortholog_one2one ) Dog_ DDX6 ( ortholog_one2many ) GuineaPig_ DDX6 ( ortholog_one2one ) Macaque_ DDX6 ( ortholog_one2one ) Mouse_ Ddx6 ( ortholog_one2one ) Pig_ DDX6 ( ortholog_one2one ) Rat_ Ddx6 ( ortholog_one2many ) Rabbit_ DDX6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DDX28, DDX42, DDX25, DDX47, DDX49, DDX20, DDX50, DDX41, DDX24, TDRD12, DDX5, DDX52, DDX56, DDX3X, DDX3Y, DDX59, DDX39B, DDX23, EIF4A3, DDX54, DDX10, DDX19A, DDX19B, EIF4A1, DDX39A, DDX55, DDX18, DDX21, DDX4, DDX1, DDX53, DDX17, DDX31, DDX51, DDX43, EIF4A2, DDX27, DDX46 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in most tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.040449(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1VEC (X-ray 2.01A ) 2WAX (X-ray 2.30A ) 2WAY (X-ray 2.30A ) 4CRW (X-ray 1.75A ) 4CT4 (X-ray 2.30A ) 4CT5 (X-ray 3.00A ) 5ANR (X-ray 2.10A ) 6F9S (X-ray 3.03A ) 6S8S (X-ray 2.21A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:22915799, ECO:0000269|PubMed:25995375, ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:31422817, ECO:0000269|PubMed:32354837}. Cytoplasm {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. Nucleus {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. Note=Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:28216671). Upon cellular stress, relocalizes to stress granules (PubMed:26184334). {ECO:0000269|PubMed:26184334, ECO:0000269|PubMed:28216671}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |