| Gene Information | |
|---|---|
| Gene Name | GPR22 |
| Organism | Homo sapiens (Human) |
| Gene Length | 433 |
| Protein Names | G-protein coupled receptor 22 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000172209 ) 3 ( ENSG00000283812 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99680 |
| Gene Card | GPR22 |
| Uniprot ID | Q99680 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | no (-0.435937975) |
| Ortholog in Animals | Alpaca_ GPR22 ( ortholog_one2one ) Dog_ GPR22 ( ortholog_one2one ) Macaque_ GPR22 ( ortholog_one2one ) Mouse_ Gpr22 ( ortholog_one2one ) Pig_ GPR22 ( ortholog_one2one ) Rat_ Gpr22 ( ortholog_one2one ) Rabbit_ GPR22 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | QRFPR, NPFFR1, HCRTR2, HCRTR1, NPFFR2, CCKBR, CCKAR, OXTR, AVPR2, AVPR1B, AVPR1A, GALR3, FFAR4, GALR1, GNRHR, GPR150 |
| Tissue | brain, heart |
| Tissue Specificity | High expression in adult and fetal heart tissue (PubMed:18539757). Expressed in the brain, with enrichment in the accumbens, amygdala, cerebellum, cortex, and hippocampus regions (PubMed:9073069, PubMed:18539757). {ECO:0000269|PubMed:18539757, ECO:0000269|PubMed:9073069}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:D4A3U0}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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